Effect of natural sources rich in calcium on treated rats induced osteoporosis

Abstract: : The present study aimed to treat female rats’ osteoporosis using natural sources rich in calcium (permeate with kiwi or fg). Thirty-two female rats weighting 150±10 g was used in this experiment. After adaptation period (7 days), rats were divided to 8 groups (four in each group); frst group worked as a control negative and other groups were injected with 1 mg Dax. /kg/bw glucocorticoid (dexamethasone) for 7 days to induce osteoporosis. Second group was considered as a positive group and other groups were treated with beverage (kiwi with permeate or fg with permeate) at different concentrations, i.e., 20, 30 and 40%. The DPPH test was recorded 69.19, 87.01, 68.95, and 44.88% for fresh kiwi, refrigerator kiwi beverage, fresh fg, and refrigerator fg beverage respectively. Meanwhile, using ABTS recorded of 32.6, 39.07, 36.66 and 41.99 Trolox/100 g for above mentioned treatments. In general, total phenol and total flavonoid values of fg treatments were high compared with kiwi treatments. The antimicrobial examination showed an increase in lactic acid bacteria due to refrigeration in both beverages and less total count. Mold, yeast, and coliform not detected. The biological assay resulted in decrease weight gain and feed intake while feed efficiency ratio slightly affected due to beverages. Ca and P content of osteoporotic femur have shown an increase more than the potassium content. Also, serum Ca, P, PTH, Vit. D and protein increased significantly as the result of beverage treatments. The X- ray showed an improved of bone in all treatments compared with (+) control. It could be concluded that permeate mixed with kiwi or fg can be used as a therapeutic diet for subjects, who suffered from osteoporosis.
Keywords: Milk permeate • Kiwi • Fig. functional beverages • Bacteria • Osteoporosis • Glucocorticoid
Publication year 2022
Organization Name
serial title Discover Food
Web Page
Author(s) from ARC
Publication Type Journal
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